Decitabine priming prior to low-dose chemotherapy improves patient outcomes in myelodysplastic syndromes-RAEB: a retrospective analysis vs. chemotherapy alone

Decitabine in myelodysplastic syndromes

RADIOTHERAPY IN IMMUNOPROLIFERATIVE SMALL INTESTINAL DISEA SE: A RETROSPECTIVE COMPA RISON OF CHEMOTHERAPY PLUS RADIATION WITH CHEMOTHERAPY ALONE

In order to evaluate the results of abdominal radiation plus chemotherapy in cases with stage II and III of immunoproliferative small intestinal disease in comparison to chemotherapy alone, fifty-one patients referred to Shiraz University of Medical Sciences' affiliated hospitals were studied between 1980 and 1994. Out of them 38 patients who had an abdominal mass were gathered into two gro...

Decitabine dosage in myelodysplastic syndromes

contained a chromosome 7 abnormality (also mostly monosomy 7). Four of 11 patients with complex karyotype including aberrations of chromosome 7 showed cytogenetic responses (Figure 1; Table 1) compared with 2 responders of 9 patients with complex karyotype not containing a chromosome 7 abnormality. This high response rate in patients with chromosome 7 abnormalities is in stark contrast to the n...

A cost-effectiveness analysis of using azacitidine vs. decitabine in treating patients with myelodysplastic syndromes.

OBJECTIVE Azacitidine and decitabine are used to treat patients with myelodysplastic syndromes (MDS) in the United States (US). This study sought to assess their relative cost-effectiveness. DESIGN AND METHODS The authors developed a cost-effectiveness Markov model (1-month cycles) tracking hypothetical cohorts of MDS patients treated with azacitidine or decitabine over 2 years. The model use...

Decitabine in the treatment of myelodysplastic syndromes

Myelodysplastic syndromes (MDS) are a group of heterogeneous clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, peripheral blood cytopenias and a propensity to transform into acute myeloid leukemia. There are few treatment options available for patients with MDS. Studies into the molecular biology of MDS have demonstrated abnormal patterns of DNA methylation th...